From the East:   From I-94, take Exit #155 (Mandan City Center), which leads to Main Street.  Turn left on 6th Ave SE.  Spirit of Life is 2 blocks on the left side.

From the West:   From I-94, take Exit # 152  (Sunset Drive) and go south (right) to Main Street.  Turn left on Main and go to 6th Ave SE.  Turn right on 6th Ave SE.  Spirit of Life is 2 blocks on the left side.

From the South:   From HWY 6, turn right on 3rd Ave. SW.  Go east to 6th Ave SE and turn left.  Spirit of Life is 1/2 block north on the right side.

From the South:   From HWY 1806 (Fort McKeen Rd), Spirit of Life is on the right side of the road just past 3rd Ave SE.